Molecular and Epidemiological Characterization of Carbapenem-Resistant Acinetobacter baumannii in Non-Tertiary Korean Hospitals
Yonsei Medical Journal
;
: 177-182, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-66224
ABSTRACT
PURPOSE:
The increasing prevalence and global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) has become a serious problem. The aim of this study was to investigate molecular and epidemiological characteristics of carbapenem-resistant A. baumannii isolates collected from Korean non-tertiary hospitals. MATERIALS ANDMETHODS:
Thirty six non-duplicated carbapenem-resistant A. baumannii isolates were collected from 17 non-tertiary hospitals in Korea between 2004 and 2006. Isolates were typed by multilocus sequence typing and repetitive-sequence-based PCR (rep-PCR). Detection of genes encoding OXA carbapenemase and their relationship with ISAba1 was performed by PCR.RESULTS:
Two clones were prevalent among 36 isolates ST69 (17 isolates, 47.2%) and ST92 (19 isolates, 52.8%). Rep-PCR patterns were diverse and revealed that all isolates were clustered into eight band patterns. The ISAba1-activated blaOXA-23-like and ISAba1-activated blaOXA-51-like genes were prevalent among the carbapenem-resistant A. baumannii isolates.CONCLUSION:
The class D beta-lactamase genes of A. baumannii were distributed nationwide in non-tertiary Korean hospitals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Beta-Lactamases
/
Infecções por Acinetobacter
/
DNA Bacteriano
/
Testes de Sensibilidade Microbiana
/
Carbapenêmicos
/
Reação em Cadeia da Polimerase
/
Prevalência
/
Técnicas de Tipagem Bacteriana
/
Epidemiologia Molecular
/
Farmacorresistência Bacteriana
Tipo de estudo:
Estudo de prevalência
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Yonsei Medical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo
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