Advance in the study of pyroptosis in renal inflammatory injury / 基础医学与临床

ABSTRACT

Pyroptosis is activated caspase-1 trigger special programmed cell. Recent studies have confirmed the py-roptosis in renal cells plays an important role. GSDMD cleavage caspase-1 regulating the downstream inflammatory cytokines maturation、release and triggering inflammation and pyroptosis. From renal inflammatory injury caused by NLRP3 activation, pyroptosis from GSDMD breakage, the review try to explain the NLRP3-caspase-1-GSDMD drived pyroptosis in renal inflammation injury to explore the essence of kidney inflammatory damage.