Correlation analysis between cardiac function classification of NYHA and homocysteine , N-terminal pro-brain natriuretic peptide ,fibrinogen ,D-dimer in patients with chronic pulmonary heart disease / 国际检验医学杂志

ABSTRACT

Objective To explore the correlation between cardiac function classification and homocysteine (HCY) ,N-terminal pro-brainnatriureticpeptide(NT-proBNP),fibrinogen(Fbg),D-dimer(D-D) in patients with chronic pulmonary heart disease (CPHD) .Methods A total of 135 cases of CHPD were divided into 4 groups by cardiac function classification of New York Heart Association(NYHA)NYHA class Ⅰ group(group A ,33 cases) ,NYHA class Ⅱ group(group B ,39 cases) ,NYHA class Ⅲ group (group C ,36 cases) ,NYHA class Ⅳ group(group D ,27 cases) .Meanwhile 50 healthy subjects were recruited into HC group .The level of HCY ,NT-proBNP ,Fbg and D-D were detected and compared between different groups .Receiver operating characteristic (ROC) curves were drawn ,the area under ROC curves(AUCs) were calculated to assess the diagnostic value of each item ,the cor-relation between cardiac function classification and HCY ,NT-proBNP ,Fbg ,D-D in CHPD was analyzed .Results Compared with HC group ,the level of HCY ,Fbg and D-D in group A didn′t rose significantly(P>0 .05) .The level of HCY ,NT-proBNP ,Fbg and D-D in group B ,C ,D were significant with those of the control group(P<0 .05) .NT-proBNP increased higher in CHPD as the du-ration of cardiac function classification of NYHA processed (P<0 .05) .The AUCs of HCY ,NT-proBNP ,Fbg ,D-D were respective-ly 0 .710 ,0 .919 ,0 .782 ,0 .864 in CHPD patients .There were significant correlations between cardiac function classification of NY-HA and HCY ,NT-proBNP ,Fbg ,D-D(P< 0 .01) .Conclusion The level of HCY ,NT-proBNP ,Fbg ,D-D could be considered as monitoring and diagnostic indexes of CHPD .