IL-33/ST2 axis in systemic lupus erythematosus in relation to chronic kidney injury and disease activity / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12): 1696-1702, 2017.
Article
em Zh
| WPRIM
| ID: wpr-662735
Biblioteca responsável:
WPRO
ABSTRACT
AIM:To elucidate the association between chronic kidney injury and interleukin-33 (IL-33;an alarmin)/suppression of tumorigencity 2 (ST2) in patients with systemic lupus erythematosus (SLE).METHODS:Serum levels of IL-33 and soluble ST2 (sST2) were assessed by ELISA in 50 SLE patients and 30 healthy controls (HC).RESULTS:The levels of IL-33 and sST2,and IL-33/sST2 ratio were significantly higher in SLE patients than those in the HC.The IL-33 and sST2 levels were positively associated with SLE disease activity index (SLEDAI),erythrocyte sedimentation rate (ESR),proteinuria and triglyceride,but negatively associated with complement C3.IL-33/sST2 ratio was positively associated with SLEDAI and estimated glomerular filtration rate (eGFR).Independent explanatory variables associated with high IL-33/sST2 included chronic kidney disease (CKD) staging and albumin (R2 =0.442),especially CKD staging.CONCLUSION:Elevated serum sST2 and IL-33 levels in SLE patients are correlated with disease activity and risk factors of kidney injury.IL-33/sST2 ratio may serve as a potential biomarker for chronic kidney injury in SLE patients.
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1
Índice:
WPRIM
Tipo de estudo:
Risk_factors_studies
Idioma:
Zh
Revista:
Chinese Journal of Pathophysiology
Ano de publicação:
2017
Tipo de documento:
Article