The study of liver macrophages polarization in patients with autoimmune hepatitis / 中华内科杂志

ABSTRACT

To explore the functional phenotype of liver macrophages in patients with autoimmune hepatitis (AIH).Compared with patients with nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis B (CHB),the absolute CD68 + cell count in patients with AIH was significantly higher (all P ＜ 0.05).It was positively correlated with ALT and IgG levels (the correlation coefficients 0.600 and 0.700,P =0.285 and 0.188 respectively).Additionally,compared with patients with NAFLD,the absolute iNOS positive cell count in patients with AIH and CHB were significantly higher (all P ＜0.05).The expression of TNFα,iNOS and IL-1β in patients with AIH and CHB were significantly higher than in patients with NAFLD (all P ＜ 0.05).Interestingly,compared with patients with AIH and CHB,the absolute CD206 + cell count in patients with NAFLD were significantly higher (all P ＜ 0.05).CD206 expression in patients with NAFLD was higher than patients with AIH and CHB,but with no statistical significance.M1 type macrophages overexpressed and played a major role in the inflammatory reaction and liver injury in patients with AIH.