A Study of a Selection of Antidotes for Paraquat induced Skin Damage
Annals of Dermatology
;
: 13-19, 1998.
Artigo
em Inglês
| WPRIM
| ID: wpr-66305
ABSTRACT
BACKGROUND:
Paraquat is a widely used herbicide, known to cause lethal toxicity in humans. Most studies about paraquat have concentrated on systemic toxicity, however several cases of paraquat-induced dermatitis have been reported.OBJECTIVE:
The purpose of this study was to confirm the cutaneous toxic effect of paraquat and to select potential antidotes in paraquat-induced dermatitis.METHODS:
Keratinocyte toxicity due to paraquat and the toxicity reduction capacity of several drugs were investigated in eitro. Topical effects of these drugs on paraquat-induced dermatitis in guinea pig skin was also investigated.RESULTS:
Over 50% of keratinocytes failed to survive at a concentration of 2X10-4M paraquat by a neutral red uptake assay. Skin irritation by paraquat was observed at 2% concentration by non-invasive methods as well as a skin biopsy. Dexamethasone, glutathione and tocopherol showed some capacity to reduce paraquat-induced keratinocyte toxicity in vitro. Only dexamethasone, however, showed a reduction of cutaneous blood flow volume and dermal inflammatory cell infiltration in the guinea pig study.CONCLUSION:
This result indicates the possible in eitro protective effect of paraquat toxicity in glutathione and tocopherol. Dexamethasone was capable of reducing paraquat-induced cytotoxicity and dermatitis both in vitro and in vivo.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Paraquat
/
Pele
/
Biópsia
/
Técnicas In Vitro
/
Dexametasona
/
Queratinócitos
/
Tocoferóis
/
Dermatite
/
Glutationa
/
Cobaias
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
1998
Tipo de documento:
Artigo
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