Recent updates on neoadjuvant chemotherapy for advanced gallbladder cancer / 中华肝胆外科杂志

ABSTRACT

Radical resection has been the only thempeutic method that can improve the long-term survival for patients with gallbladder cancer (GBC) so far.However,for advanced GBC,patients generally have poor prognosis due to late awareness of the disease and poor surgical resection rate.Sometimes,the neoadjuvant chemotherapy can downstage tumors for potential surgery thus increases the R0 resection rate,as confirmed in esophageal carcinoma,gastric carcinoma,colorectal carcinoma,and so on.Currently,the neoadjuvant chemotherapy in GBC has not been extensively performed.In this article,we will review the recent progression,current status,and effectiveness of associated regimens of chemotherapy treatment of GBC,as well as discussing the feasibility of delivering neoadjuvant chemotherapy to the patients with advanced GBC and solutions to major issues.