Effect of traditional Chinese medicine on the expression of proteinuria and inflammatory factors in diabetic kidney disease rats / 国际中医中药杂志
International Journal of Traditional Chinese Medicine
;
(6): 1103-1107, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-663325
ABSTRACT
Objective To observe the effect of traditional Chinese medicine on proteinuria and inflammatory factors on the model of diabetic kidney disease rats. Methods The male SD rats were divided into the blank group, model group, treatment group, control group. The diabetic kidney disease model was induced by using the left inferior abdominal cavity. After eight weeks, we observed the changes of the rat's weight/kidney weight, blood sugar, IL-6, urine microalbumin, MCP-1 and TGF-β. Results Compared with the model group,the blood glucose(9.96 ±3.73 mmol/L vs.17.16 ±5.75 mmol/L)and Proteinuria(11.73 ±4.01 mg/L vs.19.57 ± 8.38 mg/L,P<0.05) of the treatment group significantly decreased (P<0.05). Compared with the model group,the level of IL-6(58.87 ±14.69 ng/L vs.85.22 ±12.16 ng/L)and the MCP-1(1.52 ±0.86 ng/L vs.3.17 ± 1.26 ng/L)of the treatment group were significantly lower (P<0.05). Conclusions The Chinese medicine can reduce the FPG, proteinuria and the removal of serum inflammatory factors in diabetic kidney disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
International Journal of Traditional Chinese Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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