Analysis of influencing factor of newly diagnosed thyroid associated ophthalmopathy after radioiodine treatment of Graves disease in short term / 中国基层医药

ABSTRACT

Objective To analyze the relevant factor of newly diagnosed thyroid associated ophthalmopathy (TAO) after radioiodine treatment of Graves disease(GD) in short term.Methods A total of 19 patients with GD and TAO in three months after radioiodine treatment were selected as observation group,64 patients with GD treated by radioiodine in the same period were selected as control group.The thyrotrophic receptor antibody (TRAb),thyroglobulin antibody (TGAb),thyroid peroxidase antibody (TPOAb),tumor necrosis factor alpha (TNF-α) and the changes of thyroid function before and after treatment were compared.Results The base line levels of TPOAb,TRAb and TNF-α had no statistically significant differences between the observation group and the control group,but the ascensional range became bigger after treatment (TPOAbt =-5.632,P =0.000;TRAbt =-3.284,P =0.002;TNF-αt=-3.907,P =0.000).One month later,FT3 level increased in the observation group after treatment,but that had no significant change in the control group (t =9.475,P =0.000).After 3 months,the falling range of thyroid function had no statistically significant difference between the two groups,which suggested that the TAO was not related to hypothyroidism.The thyroid function,thyroid weight (t =0.211,P =0.833),rate of iodine intake (t =1.235,P =0.221),gender (x2 =1.554,P =0.213),age (t =0.154,P =0.878),course of disease before radioiodine treatment (Z =0.761,P =0.447) were irrelevant to the occurrence of TAO.Conclusion The rise of TRAb,TPOAb,TNF-α and thyroid function are related to TAO after radioiodine treatment.Identifying the risk factors to predispose patients with GD to develop TAO can dramatically alter the management of these patients.