Hidden varicella outbreak, Luang Prabang Province, the Lao People’s Democratic Republic, December 2014 to January 2015
Western Pacific Surveillance and Response
;
: 1-5, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-6634
ABSTRACT
OBJECTIVE:
To identify the etiology and risk factors of undifferentiated fever in a cluster of patients in Western Province, Solomon Islands, May 2014.METHODS:
An outbreak investigation with a case control study was conducted. A case was defined as an inpatient in one hospital in Western Province, Solomon Islands with high fever (> 38.5 °C) and a negative malaria microscopy test admitted between 1 and 31 May 2014. Asymptomatic controls matched with the cases residentially were recruited in a ratio of 12. Serum samples from the subjects were tested for rickettsial infections using indirect micro-immunofluorescence assay.RESULTS:
Nine cases met the outbreak case definition. All cases were male. An eschar was noted in five cases (55%), and one developed pneumonitis. We did not identify any environmental factors associated with illness. Serum samples of all five follow-up cases (100%) had strong-positive IgG responses to scrub typhus. All but one control (10%) had a moderate response against scrub typhus. Four controls had low levels of antibodies against spotted fever group rickettsia, and only one had a low-level response to typhus group rickettsia.DISCUSSION:
This outbreak represents the first laboratory-confirmed outbreak of scrub typhus in the Western Province of Solomon Islands. The results suggest that rickettsial infections are more common than currently recognized as a cause of an acute febrile illness. A revised clinical case definition for rickettsial infections and treatment guidelines were developed and shared with provincial health staff for better surveillance and response to future outbreaks of a similar kind.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Guia de Prática Clínica
/
Estudo observacional
/
Estudo prognóstico
/
Pesquisa qualitativa
/
Fatores de risco
Idioma:
Inglês
Revista:
Western Pacific Surveillance and Response
Ano de publicação:
2016
Tipo de documento:
Artigo
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