Expression and Clinical Significance of Blood IL-37 in Patients with Chronic HBV / 现代检验医学杂志
Journal of Modern Laboratory Medicine
; (4): 26-27,31, 2017.
Article
em Zh
| WPRIM
| ID: wpr-663462
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the expression levels of IL-37 in serum in chronic HBV(CHB)patients,and investigate their clinical significance in CHB patients.Methods The expression levels of IL-37 in serum from 35 CHB patients and 35 health-y controls were quantified by ELISA.This study also tested ALT,AST,HBsAg,HBeAg,HBV DNA,TNF-αand IL-10 in the serum of CHB patients,and also analyzed the relationship between the levels of IL-37 and ALT,AST,HBsAg,HBeAg, HBV DNA,TNF-α,IL-10 levels.Results The expression levels of IL-37 was increased in CHB patients 437.5±152.7 pg/ml compared to healthy donors(63.0±2.1 pg/ml).The difference between the two groups was statistically significant(t=2.45,P=0.017).The levels of IL-37 was found to correlate with ALT(r=0.406,P=0.019)and IL-10(r=0.433,P=0.035)but not AST,HBsAg,HBeAg,HBV DNA and TNF-α.Conclusion This study reveals the levels of IL-37 in CHB patients was higher than healthy controls,and IL-37 may play an important role in liver damage and HBV chronic infection.
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WPRIM
Idioma:
Zh
Revista:
Journal of Modern Laboratory Medicine
Ano de publicação:
2017
Tipo de documento:
Article