Research progress of leosimendan for treatment of septic shock / 中国中西医结合急救杂志

ABSTRACT

Sepsis is defined as a host imbalance of response induced by infection leading to life-threatening organ dysfunction, and septic shock is the most severe form of sepsis resulting from systemic circulatory and metabolic abnormalities, having high mortality rate. During septic shock stage, there are myocardial injury and myocardial inhibition, and after septic shock combined with cardiac injury, the mortality will be increased significantly. Levosimendan can improve cardiac function, hemodynamics, microcirculation, tissue oxygen metabolism, organ functions, etc in patients with septic shock. Now the effects of levosimendan on internal organ functions and hemodynamics in treatment of patients with septic shock are reviewed.