Research progress of pathogenic factors in children with hearing impairment / 国际儿科学杂志

ABSTRACT

Hearing impairment is one of the most common disabilities in children,which seriously af-fects the quality of lives as well as physical and mental development of children.Hearing impairment is high risk and harmful,which brings heavy burden to the families and society.We could take preventive measures to reduce the incidence of this disease after exploring the pathogenic factors of hearing impairment.Viral infection and nic-otine may directly or indirectly damage the vestibulocochlear organ and cause gene mutation.Noise and inflam-mation may cause direct mechanical damage and induce auditory cell apoptosis,while ototoxicity drugs may me-diate a temporary weakening or delayed auditory impairment by inner ear hair cell apoptosis,neural degeneration and repair dysfunction.There are lots of ways to cause hearing loss and the pathogenic factors of hearing loss are complex and varied.This paper reviews the aspects of fetal,neonatal,genetic,drug and other factors associated with hearing impairment.