Gut microbiota and neonate neural development / 国际儿科学杂志

ABSTRACT

Gut microbiota may be important to human health.The early colonization of gut microbiota will affect the growth and development of infants.The microbiome-gut-brain axis connects the gut microbiota to the brain,providing a communication bridge for the gut microbiota and the central nervous system,and develops in parallel with the newborn central nervous system. Gut microbiota may affect neonate neural development through metabolism,immunity,vagus nerve and neuroendocrine.Gut microbiota may also affect the permeability and integrity of neonatal blood-brain barriers by regulating the expression of tightly linked protein. In recent years,the research of gut microbiota that may regulate neonate neural development is still in its early stage,but gradually becomes a hot research topic.