Inhibitory effect of resveratrol on the hypercoagulable state in rats and its relationship with the expression of NF-κB / 中国比较医学杂志
Chinese Journal of Comparative Medicine
;
(6): 79-83, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-663890
ABSTRACT
Objective The topic of this study was to study the inhibitory effect of resveratrol on hypercoagulable state in rats and its relationship with the expression of NF-κB. Methods Rats were divided into control and model groups, and resveratrol ( high dose, 60 mg/kg ) , resveratrol ( low dose, 30 mg/kg ) and aspirin ( 10 mg/kg ) were given by intragastric administration for 7 d. Then, the rats were treated by adrenaline with ice bath or thrombin to generate hypercoagulable state. Blood samples were collected to test the prothrombin time (PT), activated partial thromboplastin time ( APTT) and blood viscosity. Vascular endothelial cells were collected to detect the expression of NF-κB by western blotting. Results PT and APTT values of rats in the control, resveratrol (high dose) and aspirin groups were significantly increased than the model group (P< 0. 05). Blood viscosity of rats in the control, resveratrol (high dose) and aspirin groups was significantly lower than the model group (P< 0. 05). The expression of NF-κB was decreased than that of the model group (P< 0. 05). Conclusions Resveratrol in high dose (60 mg/kg) can inhibit hypercoagulable state of rat, which may be related with its effect on decreasing the expression of NF-κB.
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Comparative Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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