Experimental Study on Acute Toxicity of Momordica Cochinchinensis in Mice / 中国药师

ABSTRACT

Objective:To study the acute toxicity of Momordica Cochinchinensis in mice, observe and evaluate the acute toxicity of Momordica Cochinchinensis herbs in order to provide basis for the safe and reasonable clinical medication. Methods: According to the classic experiment methods, the acute toxicity of Momordica Cochinchinensis in mice was compared with different administration meth-ods, and the LD50 was calculated by the Bliss method with the continuous administration and observation for 7 d. At the end of the tri-al, the pathologic changes of the relevant organs were also observed. Results:The LD50 of Momordica Cochinchinensis in mice with oral administration was 4. 03g·kg-1 , and the 95% confidence interval was 3. 29-4. 92 g·kg-1 . The LD50 of Momordica Cochinchinensis in mice with intraperitoneal injection was 146. 17 mg·kg-1 , and the 95% confidence interval was 118. 92-177. 31 mg·kg-1 . Conclu-sionThe Momordica Cochinchinensis extract is poisonous, which is consistent with the literatures and pharmacopoeia. By comparing the acute toxicity with different administration methods of Momordica Cochinchinensis in mice, it is beneficial to the evaluation of acute toxicity of Momordica Cochinchinensis to provide basis for the reasonable medication in clinics.