Study on the in vitro Release Characteristics of Shengmai Pulse Controlled Release Dropping Pills / 中国药师
China Pharmacist
;
(12): 2244-2248, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-664093
ABSTRACT
Objective:
To prepare Shengmai pulse controlled release dropping pills and investigate the in vitro release.Methods:
Shengmai dropping pills were placed in a fluidized bed and coated respectively with an aqueous solution of a swelling layer ( containing croscarmellose sodium) and a controlled release layer ( containing ethylcellulose aqueous dispersion) . The effects of different coating weight gain on the drug release from the swelling layer and the controlled release layer were studied by central composite design-re-sponse surface methodology and in vitro dissolution test.Results:
The weight gain of the swelling layer and the controlled release layer was 20% and 10%, respectively, and the expected release time was 4 h.Conclusion:
By adjusting the coating weight gain, the drop-ping pills with different release time can be obtained.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2017
Tipo de documento:
Artigo
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