Safety and Feasibility of Thallium-201 Myocardial SPECT with Intravenous Infusion of Disodium Sdenosine Trophosphate ( ATP ) in the Diagnosis of Coronary Artery disease / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 250-258, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-66419
ABSTRACT
PURPOSE:
ATP (adenosine triphosphate) is a potent coronary vasodilator with a rapid onset of action and a very short half-life. Myocardial perfusion scintigraphy with intravenous ATP has not yet been sufficiently proven in the diagnosis, follow-up, and risk stratification of coronary artery disease. The purpose of this study was to evaluate the safety, feasibility and diagnostic accuracy of pharmacologic stress thallium-201 myocardial SPECT using an intravenous ATP infusion in patients with suspected coronary artery disease. MATERIALS ANDMETHODS:
Thalliurn-201 myocardial SPECT in 319 patients with suspected coronary artery disease were performed after the infusion of ATP (0.08 mg/kg/min for 6 rnin). The adverse effects were carefully monitored. Coronary angiography was also performed within 3 weeks.RESULTS:
Although 76.5% of the patients had sorne adverse effects, they were transient, mild, and well tolerated. In all patients, the ATP infusion protocol was completed and only 2 patients required aminophylline. The adverse effects were dyspnea in 63%, headache in 31%, flushing in 21%, chest pain in 14% and abdominal discomfort in 5% of the patients. The sensitivity and specificity were 80% and 90% respectively.CONCLUSION:
Thallium-201 myocardial SPECT after 6 min-infusion of ATP at a rate of 0.08 mg/kg/min is safe and has a diagnostic value in detecting coronary artery disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor no Peito
/
Doença da Artéria Coronariana
/
Infusões Intravenosas
/
Tomografia Computadorizada de Emissão de Fóton Único
/
Trifosfato de Adenosina
/
Seguimentos
/
Sensibilidade e Especificidade
/
Angiografia Coronária
/
Vasos Coronários
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Guia de Prática Clínica
/
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Nuclear Medicine
Ano de publicação:
1998
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS