Research progress of heat shock protein 70 in hepatocellular carcinoma / 实用肿瘤学杂志

ABSTRACT

Heat shock protein 70(HSP70)is a highly conserved polypeptide protein,which plays an im-portant role in protein homeostasis,apoptosis,invasion and cell signaling transduction. Many studies have shown that the expression level of HSP70 is closely related to the development and progression of tumor,which is a low expression in normal tissues and the overexpression in tumor tissue. Hepatocellular carcinoma ( HCC ) is con-cealed,and the related study reported that the expression of HSP70 can be used as a sensitive biological index for the diagnosis and differential diagnosis for early HCC,and also affects the treatment and prognosis of patients with HCC. This article will summary the relationship between the expression of HSP70 and HCC.