The distribution of vitamin D receptor gene polymorphisms in patients with chronic obstructive pulmonary disease in Changsha / 中国医师杂志
Journal of Chinese Physician
;
(12): 1615-1617, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-664595
ABSTRACT
Objective To investigate the genetic predisposing factor of chronic obstructive pulmonary disease (COPD) by studying the distribution of vitamin D receptor (VDR) gene polymorphisms in patients with COPD in Changsha.Methods Totally 120 COPD patients and 120 volunteers were enrolled in the study.Polymorphisms of VDR genes including Apa I and Bsm I were detected with polymerase chain reaction-restriction fragments length polymorphism (RFLP).Results There existed statistical difference in polymorphism of Apa I gene and frequency of distribution on its allele between two groups (P < 0.05),while there is no significant difference on Bsm I gene between the two groups (P > 0.05).Conclusions COPD is associated with the polymorphism of VDR-Apa I.There may be no relationship on VDR-Bsm I between two groups.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Chinese Physician
Ano de publicação:
2017
Tipo de documento:
Artigo
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