Predictive Value of Risk Factors Model for Major Adverse Cardiac Events in Patients with Intermediate Coronary Stenosis in Proximal Left Anterior Descending Artery / 医学研究杂志

ABSTRACT

Objective To investigate the risk factors of major adverse cardiac events (MACE) in patients with intermediate coronary stenosis in proximal left anterior descending artery (ICS-PLAD) and to assess the predictive value of risk factors model for MACE in patients with ICS-PLAD.Methods Totally 221 patients with ICS-PLAD (≥50％ and ＜70 ％ diameter stenosis by angiography) were retrospectively studied.The risk factors of MACE in patients with ICS-PLAD were explored by binary logistic regression analysis.The predictive value of risk factors model for MACE in patients with ICS-PLAD was evaluated by receiver operator curves (ROC).Results Compared with No MACE group,the MACE group had more patients with diabetes(DM),hypertension and number of stenotic vessels ≥ 2,had higher body mass index (BMI),low density lipoprotein cholesterol(LDL-C)and triglycerides(TG) (P all ＜ 0.05).Binary logistic regression analysis showed that the independent risk facts were TG (OR =2.447,P =0.000,95％ CI1.608-3.725),LDL-C (OR =1.971,P =0.006,95 ％ CI1.219-3.187) and number of stenotic vessels ≥ 2 (OR =6.596,P =0.000,95 ％ CI2.995-14.526).The area under the ROC (AUG) of risk factor model for the prediction of MACE in patients with ICS-PLAD were 0.794 (P =0.000).Conclusion Patients with ICS-PLAD,with DM,hypertension,number of stenotic vessels ≥2,obesity,high LDL-C or high TG,had higher MACE rate.TG,LDL-C and number of stenotic vessels ≥2 were the independent risk factors of MACE in patients with ICS-PLAD.The risk factors model has some clinical value for the prediction of MACE in patients with ICS-PLAD.