Vital role of transporters in renal drug elimination / 药物评价研究

ABSTRACT

Transporters are a class of functional membrane proteins which are broadly expressed in the kidney and play a vital role in the reabsorption and secretion of many endogenous and xenobiotic compounds by the kidney.The renal proximal tubule is the primary site of transporter-mediated active transport for many drugs,including organic anion drugs,organic cation drugs and peptide drugs.Transporter-mediated drug-drug interactions may occur in the kidney when some drugs are co-administration.In this review,we focus on the location and function of major transporters in the kidney and summarize their vital role in renal drug elimination.