Influence of different hemoglobin target value on survival quality and mortality rate of maintenance hemodialysis patients / 重庆医学

ABSTRACT

Objective To analyze the influence of different hemoglobin target value on the survival quality and mortality rate of maintenance hemodialysis (M HD) patients .Methods A total of 320 patients aged 18-80 years old with end stage renal disease (ESRD) and continuous outpatient hemodialysis for over 6 months in the Hengshui Municipal Hemodialysis Center were randomly divided into the three groups .The high ,middle and low hemoglobin target values were formulated ,the group A95-110 g/L ,group B110-125 g/L and group C125-140 g/L .Each group was given the medication intervention for correcting anemia and reaching its target value .The biochemistry and coagulation related indicators were observed during following 72 weeks .After the end of ex-periment ,the SF-36 survival quality assessment was performed and then the influence of different target hemoglobin values on the patients′survival quality of life and mortality rate was analyzed .Results The various laboratory indicators before experiment had no statistically significant difference among the three groups (P>0 .05) .But the serum albumin and prealbumin levels at 12 weeks after medication intervention during the same period in the group A began to be lower than those in the group B and C ,the C-reac-tive protein(CRP) level in the group A was higher than that in the group B and C ,the difference was statistically significant (P<0 .05) .But the fibrinogen had no statistical difference among the three groups ,and CRP ,serum albumin and prealbumin levels had no statistical difference between the group B and C (P>0 .05) .the SF-36 scale evaluation in the group B and C was superior to that in the group A ,the difference was statistically significant (P<0 .05) ,while which had no statistical difference between the group B and C (P>0 .05) .After the experiment end ,the mortality rate showed no statistically significant difference among the three groups (χ2 =0 .467 ,P=0 .792) .Conclusion The correction of anemia has close relation with biochemistry ,coagulation ,serum albumin , prealbumin and survival quality .The hemoglobin target value setting should be formulated according to the specific circumstances of patients .