Roles of macrophage-mediated epithelial mesenchymal transdifferentiation in fibrotic diseases / 中华危重病急救医学
Chinese Critical Care Medicine
;
(12): 91-93, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-665223
ABSTRACT
It is reported that fibrotic changes seemed to be associated with poor prognosis in patients with organ dysfunction, unfortunately no effective treatment existed currently. Recent studies have demonstrated that macrophages can interact with epithelial cells to induce epithelial mesenchymal transdifferentiation (EMT) which is thought to play a key role in the pathogenesis of a variety of fibrotic diseases. Therefore, this review will summarize the potential role of macrophages in the molecular mechanisms of EMT-associated fibrosis. We aimed to provide a possible therapeutic approaches for the fibrotic diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Critical Care Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS