Hirshfeld Surface and Structure Analysis of Two Co-crystal of Isonicotinic Acid Hydrazide / 医药导报
Herald of Medicine
;
(12): 12-15, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-665263
ABSTRACT
Objective Two co-crystals of isonicotinic acid hydrazide(INH)-malonic acid and INH-glutaric acid were prepared.The formation mechanism and intermolecular interaction were studied. Methods Three-dimensional structure of 2 co-crystals were obtained though single crystal X-ray diffraction(SXRD), and intermolecular interaction was analyzed using Hirshfeld surface method. Results INH-malonic acid crystalized in stoichiometric ratio of 10.5,while INH-glutaric acid in 11.Two co-crystals maintain their stable arrangement in space by hydrogen bond and van der Waals force. Conclusion With the existence of pyridine ring and carbohydrazide group in INH,which mainter-molecular interaction in co-crystal can be directly and clearly revealed by Hirshfeld surface analysis.
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DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Herald of Medicine
Ano de publicação:
2018
Tipo de documento:
Artigo
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