Role of Rho GTPases in the immune regulation of infection and inflamma-tion / 中国血吸虫病防治杂志

ABSTRACT

The Rho subfamily of GTPase belongs to the Ras superfamily of small GTP binding protein,it is a nucleotide de-pendent protein,which plays a"molecular switch"function in the signal transduction process and control of numerous signaling pathways. Rho protein has many biological effects on cytoskeleton or target proteins as a signal converter in signal transduction , such as the regulation of membrane transport function,cell migration,cell adhesion,and cell proliferation. It also plays a very important role in the infection and immune inflammation of the body. Rho protein is widely distributed in related immune cells , such as T cells,B cells,NK cells and so on. When the body is infected by microorganism,the immune inflammatory reaction will be regulated through a series of signal transduction mechanism,and Rho GTPases signal transduction mechanism is one of the important signal pathways. In this paper,we conclude that Rho GTPases how to regulate the body's immune response through its signal pathway,and ultimately affect the body's immune response.