Detection of ApoE gene polymorphism and serum Lp-PLA2 levels in patients with AD and sleep disorders / 实用医学杂志

ABSTRACT

Objective To investigate the association between apolipoprotein E(ApoE)gene polymorphism and serum lipoprotein-associated phospholipid(Lp-PLA2)level in patients with AD and sleep disorders. Methods Sixty-two AD patients and 26 healthy controls were enrolled in this study.The polymorphisms of ApoE gene and lev-els of serum Lp-PLA2,IL-6 and other serological indexes were determined,respectively.The mini-mental state ex-amination(MMSE)and Pittsburgh sleep index scale(PSQI)were used to evaluate the cognition and sleep status of AD patients and healthy controls. Results(1)ApoE ε3/4 and ε2/4 genotype were significantly higher in AD patients with sleep disorders(AD-1 group)compared with the healthy controls(P<0 05),and ApoEε3/4 genotype was significantly higher in patients in AD-1 group compared with AD patients without sleep disorder(AD-2 group) (P < 0 05).(2)The ApoEε4 allele frequency in patients in AD-1 group was significantly higher than that in pa-tients in the control group(P<0 05).(3)Levels of serum Lp-PLA2 and IL-6 were significantly higher in AD pa-tients with the ApoEε4 allele compared with AD patients without the ApoEε4 allele(P < 0 05). Conclusion ApoE gene polymorphism has a certain relationship with levels of serum Lp-PLA2 and IL-6 in patients with AD and sleep disturbance,and it′s speculated that the effect of ApoE gene polymorphism on sleep disorder may be associat-ed with inflammatory reaction.