Research progress of hemorrhagic shock and encephalopathy syndrome / 中华实用儿科临床杂志

ABSTRACT

Hemorrhagic shock and encephalopathy syndrome (HSES)is a devastating disease in infants which was first proposed by Levin in 1983. The main clinical manifestations of HSES are associated with acute onset of high fever,diarrhea,rapidly followed by convulsions,unconsciousness,bleeding tendency,shock and multiorgan dysfunction. The pathological manifestations include punctate bleeding,necrosis or inflammatory changes in multiple organs. The etiology of this syndrome is unknown,and the prognosis is poor. Despite intensive treatment,the fatality rate is still high and the survival is often associated with severe neurological sequelae. At present,there is no effective treatment for this disease,and mainly early symptomatic and supportive treatment can be obtained.