Acute necrotizing encephalopathy / 中华实用儿科临床杂志

ABSTRACT

Acute necrotizing encephalopathy (ANE)is a rare type of acute encephalopathy which occurs secondary to virus infection. Individuals who suffer from ANE usually have an exaggerated immune response to various viral infections. The pathologic change is focal vascular injury which leads to destruction of the blood - brain barrier and vascular permeability that cause brain edema,petechial hemorrhage,and necrosis. The imageological changes of ANE have diagnostic significance which show multifocal,symmetric brain lesions including bilateral thalamus 100％ invol-ving. Intravenous glucocorticoids,immunoglobulin,and plasmapheresis should be effective for treatment.