Activity of serum superoxidein in patient with thyroid associate diseases / 中国现代普通外科进展

ABSTRACT

Objective:To study the activity of superoxide dismutase (dismutase superoxide,SOD) in peripheral blood of patients with thyroid associated diseases.Methods:84 cases of patients with thyroid cancer,21 cases of patients with nodular goiter,75 cases of patients with hyperthyroidism,56 cases of patients with hypothyroidism and 63 cases of normal control were collected,serum enzyme activity of SOD was detected by enzyme method,FT3,FT4 and TSH levels were detected by electrochemiluminescence assay.Student-t,Mann-whitney-U or Kruskal-Wallis was applied to analyse the different of SOD activity in different groups.Pearson correlation analysis were applied to analyze the correlation of SOD activity with thyroid hormone levels.Results:SOD activity in thyroid cancer group (164.536 ± 18.095) U/ml was significantly lower than that in hyperthyroidism group (173.376 ± 15.942) U/ml,hypothyroidism group (174.827 ± 19.895) U/ml and normal control group(179.529 ±11.625) U/ml(P＜0.05),SOD activity in nodular goiter group(157.667 ± 15.189) U/ml was significantly lower than that in hyperthyroidism group (173.376 ± 15.942) U/ml,hypothyroidism group (174.827 ± 19.895) U/ml and normal controls (179.529 ± 11.625) U/ml (P＜0.05).There were positive correlation of FT3,FT4 levels respectively with SOD activity in thyroid cancer group(r=0.346 P＜0.05,r=0.3278,P＜0.05),and there was positive correlation of FT3 level with SOD activity in normal control group (r=-0.5522.P＜0.05).Conclusions:SOD activity decreased in nodular goiter and thyroid cancer,so it could be used to observe the damage of thyroid tissue.Furtherly,it might be used as an auxiliary index in the diagnosis of thyroid tumors.