Prevalence and genotype distribution of human papilloma virus in Guangxi / 医学研究生学报

ABSTRACT

Objective To investigate the prevalence and genotype distribution of human papillomavirus (HPV) in the region of Guangxi.Methods We retrospectively analyzed 15774 individuals from the Outpatient and inpatient Unit as well as Physical Examination Departments of the People's Hospital of Guangxi Zhuang Autonomous Region between May 2010 and March 2017.Exfoliated c ellsor swab specimens were collected,and the genotypes of HPV were determined by Polymerase Chain Reaction (PCR) and reverse blot assay.Results The prevalence of HPV infection was 38.54％ (6080/15774).The infection rate of single genotype and multiple genotypes were 25.60％ (4038/15774) and 12.95％ (2042/15774),respectively.In single infection patterns,the most common genotypes included HPV 6 (10.54％,1663/15774),52 (3.91％,616/ 15774),16 (2.16％,340/15774),11 (2.14％,338/15774),and 58 (2.00％,316/15774).While among the multiple infections patterns,HPV 52+53 (4.26％,87/2042) and 52+58 (3.23％,66/ 2042) were common,and followed by HPV 16+43 (2.40％,49/2042),16+52(2.30％,47/2042),6+42 (2.15％,44/2042) and 6+43 (2.15％,45/2042).HPV 52,16,58,51,53 and 18 were the top six high risk (HR) genotypes of HPV,accounting for 26.77％ (4222/15774,95％ CI =26.08-27.46);while HPV 6,11 and 43 were the leading low-risk (LR) genotypes of HPV,accounting for 27.77％ (4380/15774,95％CI =27.07-28.47).The overall ratio of single infection to multiple infections was 1.98 (4038 vs.2042).Conclusion HPV 6,52,16,11,58,18 were the main HPV infection genotypes,and 52+53 and 52+58 were common infection combinations in Guangxi Zhuang Autonomous region.The HPV multiple infections were increased.Apparently,more HPV low risk genotypes were seen in male patients that should be aware.