Topical 5-aminolevulinic acid photodynamic therapy with stick light for the treatment of intra-anal condyloma acuminata / 医学研究生学报

ABSTRACT

Objective Intra-anal condyloma acuminate (IACA) remains a focus in clinical studies for its increasing incidence,difficult treatment and high recurrence.This study was to observe the effect and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with stick light in the treatment of IACA.Methods We treated 30 IACA patients by ALA-PDT with stick light,with the exposure time of 30-40 minutes,once a week for 3 weeks.We recorded the skin lesion,the rate of its removal,and ad verse reactions and followed up the patients for 12 months.Results One-time complete removal of the lesion was achieved in 20％ (6/ 30) of the patients and partial removal in 40.0％ (12/30);twotime complete removal in 36.7％ (11/30) and partial removal in 30.0％ (9/30);and three-time complete removal in 50.0％ (15/30) and partial removal in 23.3％ (7/30),with a total effectiveness rate of 73.3％ (22/30).Pain was the main adverse reaction in most of the patients,which reached the peak at 10 minutes and was alleviated at 15 minutes after treatment,with the Visual Analogue Scale pain score of 6.57± 1.24.Recurrence was observed in 4 cases (18.2％),2 in the anal canal and the other 2 in both the anal canal and the crissum.Conclusion ALA-PDT with stick light is safe and effective in the treatment of intra-anal condyloma acuminata.