The Study on Maternal Plasma Placental Growth Factor Level and the Perinatal Outcome in Early-Onset Pre-Eclampsia Patients / 实用妇产科杂志

ABSTRACT

Objective:To investigate the relationship between plasma placental growth factor(PIGF) levels and perinatal outcomes in patients with early onset preeclampsia(EOPE).Methods:125 patients with EOPE undergoing cesarean section were enrolled in this study.Enzyme-linked immunosorbent assay(ELISA) was used to detect the level of maternal plasma PIGF.According to the plasma PIGF level,≤ 12 pg/ml was divided into PlGF≤12 pg/ml group(n =64) and PIGF ＞12 pg/ml was in PIGF ＞12 pg/ml group(n =61).The blood gas analysis and the level of lactic acid(LAC) were measured within 1 hour after fetal birth.The routine and biochemical indexes of two groups and their relation with perinatal outcomes were compared.Results:①In PIGF ≤ 12 pg/ml EOPE group,the Hb,HCT,24h urine protein level,BUN and Cr levels were higher than those in PIGF ＞ 12 pg/ml group (P ＜ 0.05).While the ALB level was lower than that of PIG F ＞ 12 pg/ml group (P ＜ 0.05).②The gestational age of PIGF≤12 pg/ml group was less than that of PIGF ＞ 12 pg/ml group,but the proportion of oligohydramnios,meconium stained amniotic fluid and less than gestational age infants(SGA) were all higher than those of PIGF ＞ 12 pg/ml group(P＜0.05).③In the PIGF≤12 pg/ml group,neonatal birth weight(BW),1 minute Apgar score,pH,serum Ca,BE were all lower than those in PIGF ＞12 pg/ml group.But the level of LAC and the NICU hospital stay were all higher than those in PIGF ＞ 12 pg/ml group (P ＜ 0.05).Conclusions:In EOPE patients,plasma PIGF level has certain clinical value in predicting perinatal outcome.If PIGF is ≤ 12 pg/ml,the maternal renal dysfunction may be more obviously,and there is higher incidence of oligohydramnios,meconium stained fluid,SGA and neonatal asphyxia,and the newborn is more susceptible to metabolic imbalance and acid-base disorders.Mother and child care should be strengthened.