Research progress of sodium-dependent phosphate transporter in gout/hyperuricemia / 基础医学与临床

ABSTRACT

Sodium-dependent phosphate cotransporter is encoded by the solute carrier family 17 gene.The gene is located on chromosome 6 and is an important transporter of the organic anion as the substrate and is expressed in kidney and other tissues .Among them, the sodium-dependent phosphate transporter type 1, 3, and 4 have the func-tion of transferring uric acid , and abnormal function can lead to the decrease of uric acid excretion , which can cause hyperuricemia and even induce gout .