AMH in Osteoporosis: Correlation with Bone Biochemical Markers and Estrogen / 现代检验医学杂志

ABSTRACT

Objective To assess the serum level of anti-Mullerian hormone (AMH) in premenopausal women with osteoporosis and its correlation with bone biochemical markers and estrogen (E2).Methods From December 2014 to March 2016,159 subjects of premenopausal women in the osteoporosis outpatient clinic of Xi'an Honghui Hospital were selected.According to the bone mineral density (BMD),the patients were divided into osteoporosis group (43 cases),osteopenia group (56 cases),bone mass normal group (60 cases).AMH,E2,TPINP,OC,β-CTX,25(OH)D and PTH were measured by automatic electrochemiluminescence immunoassay system (ECLIA).T-test and Pearson correlation analysis were used to describe the statistics.The date with statistical significance were analyzed by receiver operating characteristic(ROC) curve.Results The serum AMH level in osteoporosis and osteopenia groups were respectively lower than the normal group (t=-6.183～-0.956,P=0.000～0.040).The TPINP,OC,β-CTX and PTH in osteoporosis were much higher than the normal group (t=3.159 ～ 5.973,P=0.000 ～ 0.010),all of them was a statistical significance.The 25 (OH)D had no statistical significance between the three groups (t=-0.938～-0.469,P=0.351～0.640).The serum AMH level of three groups firstly increased (20～25) and then decreased (＞25) with age increasing.AMH was positively correlated with BMD (r=0.422,P=0.000),but negatively correlated with TPINP (r=-0.184,P =0.020),β-CTX (r=-0.173,P=0.030),OC (r=-0.238,P=0.003).There were no correlation with E2 (r=0.150,P=0.059),25(OH)D (r=0.036,P=0.652),PTH (r=-0.140,P=0.078).The area under the ROC curve was 0.728.Conclusion The serum AMH level was a better parameter for predicting low bone mass.