Analysis of the effect of omeprazole and famotidine in the treatment of reflux esophagitis / 中国基层医药

ABSTRACT

Objective To investigate the effects of omeprazole and famotidine in the treatment of reflux esophagitis.Methods 75 patients with reflux esophagitis were selected as the research subjects,they were randomly divided into three groups according to the digital table,25 cases in each group.One group was treated with omeprazole,treatment group received oral famotidine,another group was given omeprazole combined with famotidine.The treatment effect of the three groups was observed.The improved situation of endoscopic examination,the quality of life and related symptoms before and after treatment were observed.Results The total effective rate of the combined group was 96.00％,which was higher than that of the other two groups,which of the omeprazole group was higher than that of the famotidine group (x21 =4.16,x22 =14.28,all P ＜ 0.05).After treatment,the symptom score of the combined treatment group was the lowest,heartburn [(0.49 ± 0.15) points] (t1 =3.20,t2 =11.21),acid reflux [(0.59 ±0.34) points] (t1 =2.93,t2 =9.10),chest pain[(0.66 ±0.24) points] (t1 =3.28,t2 =9.36),then was the omeprazole group.The quality of life score of the combined group was (85.62 ± 3.03) points,which was higher than that of the other two groups,which of,the famotidine group was the lowest (t1 =6.36,t2 =16.85,all P ＜ 0.05).Conclusion Omeprazole combined with famotidine in the treatment of reflux esophagitis has better clinical effect.