A analysis for cerebrospinal fluid characteristics of suppurative meningitis of newborn and abnormalities manifestation of brain MRI / 中国医学装备

ABSTRACT

Objective: To analyze the clinical manifestation of suppurative meningitis of newborn, characteristics of cerebrospinal fluid (CSF) and the abnormal manifestation of brain MRI. Methods: The clinical documents of 87 newborn with suppurative meningitis were implemented by using retrospective research, and these patients were divided into refractory group (47 cases) and common group (40 cases) according to the ease or difficulty level. And the clinical appearance and radiography characteristics of brain MRI about suppurative meningitis for newborn were analyzed. Results: In the 87 cases, 38 cases (43.68%) were positive in the culture of blood or cerebrospinal fluid (CSF). The occurrence rate of convulsions of refractory group was significantly higher than that of common group (x2=-5.187, P<0.05). The differences of glucose concentration, protein concentration and white cell count between the two groups, respectively, were significant (x2=-4.471, x2=-4.433, x2=-5.739, P<0.05). The abnormal rate of brain MRI of refractory group was significantly higher than that of common group (x2=3.227, P<0.05). The hospital stay time of refractory group was significantly longer than that of common group (t=4.815, P<0.05). Conclusion: The newborn with suppurative meningitis more likely becomes refractory suppurative meningitis when the pathogenic bacteria culture of CSF or blood is positive, and the glucose concentration in CSF is reducing and newborn occurs convulsions. The brain MRI of refractory suppurative meningitis often occurs series of abnormal manifestation including of the white matter reducing in the periphery of ventricle, ventricle expansion or cerebral external gap and so on.