Expression of HIF-1α and BCL-2 in salivary adenoid cystic carcinoma and its clinical significance / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
; (12): 728-732, 2017.
Article
em Zh
| WPRIM
| ID: wpr-667903
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WPRO
ABSTRACT
Purpose To investigate the relationship of HIF-1α,BCL-2 and clinicopathological features in salivary adenoid cystic carcinoma by detecting the levels of two proteins.Methods Immunohistochemical of SP staining assay was used to detect the level of HIF-1α and BCL-2 expression in fifty-six section from primary resection of salivary adenoid cystic carcinoma.Furthermore,the correlation between the expressions of two proteins with clinical data was evaluated through differently statistical analysis.Results Thirty-six samples (64.3%) were found to express HIF-1α.The level of HIF-1α was significantly correlated with TNM stage of tumors and the primary site of salivary adenoid cystic carcinoma (P < 0.05).Positive BCL-2 expression was detected in fifty-five cases (98.2%).The level of HIF-1 α was positively correlated with that of BCL-2 (P < 0.05)and the significant correlation between HIF-1α and TNM stage was dependent upon the strong expression of BCL-2 (P < 0.05).Conclusion It is therefore indicated that the expression of HIF1α and BCL-2 may influence the clinical stage of salivary adenoid cystic carcinoma.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical and Experimental Pathology
Ano de publicação:
2017
Tipo de documento:
Article