Decrease of Proapolipoprotein AI was Associated with Poor Prognosis in Patients with Septic Shock
Journal of the Korean Society of Emergency Medicine
;
: 231-241, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-66821
ABSTRACT
PURPOSE:
Proteomics is a peptide screening approach to identify proteins related to physiological and pathological changes. Our objective was to analyze changes in serum proteome profiles in patients suffering from septic shock, during the first 24-h period of therapy and to determine whether these changes were associated with prognosis.METHODS:
This was a retrospective observational study based on prospectively collected data that was conducted in an emergency intensive care unit (ICU) of a tertiary referral hospital. Consecutive patients admitted to the ICU with septic shock were enrolled. We obtained serum samples from the patients at admission (0 h) and 24 h after admission (24 h). Then, we analyzed the serum proteome profiles, performed Western blots, and measured serum lipid profiles.RESULTS:
Twenty-seven patients were enrolled. Thirteen patients were grouped into the survivors (SURV) group and fourteen into the non-survivors group on day 30 (NON-SURV). Proteomic analyses and Western blot showed that the expression intensities of proapolipoprotein AI remained unchanged in SURV but decreased in NON-SURV during the first 24-h period of septic shock (p=0.015). Serum high density lipoprotein (HDL) cholesterol level also remained unchanged in SURV but decreased in NON-SURV (p=0.036).CONCLUSION:
The decrease in serum proapolipoprotein AI expression during the first 24-h period of therapy was associated with a consistently low serum HDL cholesterol level and a poor prognosis in patients with septic shock.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Choque
/
Choque Séptico
/
Estresse Psicológico
/
Proteínas
/
Programas de Rastreamento
/
Western Blotting
/
Colesterol
/
Estudos Prospectivos
/
Estudos Retrospectivos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of the Korean Society of Emergency Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
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