The progress of the complement system with the pediatric relevant diseases / 中华检验医学杂志

ABSTRACT

The complement system is a complex protein network and as one part of the innate immune system.It is actived by inborn or the adaptive immune system and defends against invading pathogens,removes immune complexes and damaged self-cells,and engages with the adaptive immune response.Genetic abnormalities and (or) defective complement regulators can damage the host cell and result in several autoimmune and (or) immune inflammatory diseases.This review summarizes recent advances on the roles and detections of complement system proteins in some pediatric complement-relevant diseases.