Mechanical properties of a osteoporotic rat model after treated withXianling Gubao Capsule / 中国组织工程研究

ABSTRACT

BACKGROUND: The effect of Xianling Gubao Capsule for the elderly female osteoporotic animal models assessed by compression and bending mechanical properties is little reported.OBJECTIVE: To investigate the curative efficacy of Xianling Gubao Capsule, alendronate sodium, calcium carbonate and parathyroid hormone (3-34) for an osteoporotic rat model through compressive and bending tests at the femur.METHODS: The rat models of osteoporosis were established by bilateral ovariectomy, and were then subjected to the treatment of Xianling Gubao Capsule, alendronate sodium, calcium carbonate and parathyroid hormone (3-34),respectively, for 20 weeks. Afterwards, the rats were killed by cutting the abdominal aorta, and then the bilateral femurs were removed to undergo compressive and bending tests.RESULTS AND CONCLUSION: The compressive test the elastic stress, elastic load, elastic strain, elastic displacement,maximum load, maximum strain, maximum stress, maximum displacement and elastic modulus in the model group were significantly lower than those in the blank control, Xianling Gubao Capsule, alendronate sodium and parathyroid hormone (3-34) groups (P < 0.05). The maximum load, maximum strain, maximum stress, and maximum displacement did not differ significantly between Xianling Gubao Capsule and blank control groups (P > 0.05). All indexes in the compressive and bending tests showed no significant differences between model and calcium carbonate groups (P >0.05). Bending test the maximum load, maximum stress, maximum strain, maximum bending moment and bending section modulus in the model group were significantly lower than those in the blank control, Xianling Gubao Capsule,alendronate sodium and parathyroid hormone (3-34) groups (P < 0.05). The bending mechanical indexes showed no significant differences between Xianling Gubao Capsule and blank control groups (P > 0.05). To conclude, after compressive and bending tests, Xianling Gubao Capsule, alendronate sodium, and parathyroid hormone (3-34) all restore the mechanical properties of the femur, and Xianling Gubao Capsule obtains a significant curative efficacy.