Clinicopathologic features of metastatic gastrointestinal stromal tumors / 临床与实验病理学杂志

ABSTRACT

Purpose To explore the clinicopathologic features of metastatic gastrointestinal stromal tumors (GIST) and the mechanism of lymph node metastasis.Methods 45 cases of surgical specimens with metastasis were selected as the research object and 50 cases of primary tumors in the same period were compared.All materials were stained with immunohistochemical method that marked Ki-67,CD31,D2-40,and then micro vessel density (MVD) and lymphatic microvessel density (LMVD) in each group were calculated.Results The total metastatic rate was 5.45％,the blood metastatic rate was 1.33％ and the lymph node metastatic rate was 1.09％.MVD of metastatic GIST was 398.39 ± 68.20/mm2and MVD of non-metastatic GIST was 192.07 ± 56.85/mm2,and the difference between them was statistically significant.There was no lymphatic vessels distribution in the essence of GIST regardless of metastasis.About metastatic GIST,LMVD of the edge area of the essence was 13.28 ±2.40/mm2 and LMVD of normal tissue around the essence was 25.36 ± 6.71/mm2.In regard to non-metastatic GIST,LMVD of the edge area of the essence was 12.21 ± 1.83/ mm2 and LMVD of normal tissue around the essence was 24.23 ± 8.64/mm2.No statistically significant existed between LMVD of the edge area of the essence and LMVD of normal tissue around the essence.All of the 9 cases of lymph node metastatic GIST and 12 from 86 cases of non-metastatic GIST showed invasive growth.Conclusion MVD of metastatic GIST is higher than that of non-metastatic GIST.There is no lymphatic vessel within the essence of GIST.The invasive growth way may be the cause of the lymph node metastasis.