A randomized controlled study of vitamin D3 supplementation on childhood asthma control / 重庆医学

ABSTRACT

Objective To explore the effect of vitamin D3 supplementation on childhood asthma control for the purpose of providing a scientific basis for preventing the recurrence of childhood asthma.Methods A total of 92 children with asthma enrolled from January 2015 to December 2015 was divided into vitamin D group and placebo group by adopting double-blind randomized controlled design principles.Two groups were given a dose of 800 IU of vitamin D3 and placebo respectively,1 tablet per day for 2 months of treatment.The levels of asthma control and serum 25-hydroxy vitamin D3 and lung function index were examined at baseline,2 months and 6 months.Results A total of 83 patients completed the entire follow-up,including 43 patients in the vitamin D group and 40 patients in the placebo group.After 2 months,the level of asthma control in the vitamin D group was significantly higher than that in the placebo group(P=0.015) and the level of serum 25-hydroxy vitamin D3 was also higher in the vitamin D group than in the placebo group(P=0.042).There was no significant difference of pulmonary function index between the two groups(P＞0.05).After 6 months,the level of asthma control in the vitamin D group was still higher than that in the placebo group with no significant difference(P=0.094).There was no significant difference in the level of serum 25-hydroxy vitamin D3 between the two groups.The percentage of the less than 80％ peak expiratory flow rate(PEF％) was significantly decreased in the vitamin D group(P=0.029).Conclusion Short-term low-dose vitamin D supplement can enhance the level of asthma control and has positive clinical application value.