Difference expression of CK19, CD56, p53 and its significance in PMC and papillary hyperplasia / 中国现代普通外科进展

ABSTRACT

Objective:To investigate the difference expression of CK19,CD56,p53 and its significance in PMC and papillary hyperplasia.Methods:112 cases of papillary thyroid microcarcinoma and papillary thyroid hyperplasia were selected as the experimental materials from 2013 to 2015 years,compare the expression of CK19,CD56 and p53in the tissues of PMC and PTC;To analyze the relationship between the expression of CD56 and p53 in PMC tissue and pathological parameters.The efficacy analyzed of CK19,CD56 and p53 in the differential diagnosis of PMC and PTH.Result:Expression positive rate of CK19 and p53 in PMC(100％ and 65.33％) was higher than that of PTH (32.43％ and 13.51％),CD56 expression positive rate in PMC (6.67％) was lower than that of PTH (62.16％),and the difference was statistically significant (P＜0.05).The positive rate of CK19 expression in PMC was not statistically significant difference in gender,age,lesion size,lymph node metastasis,TNM stage and differentiation degree(P＞0.05).TNM stage Ⅲll+ⅣV patients with p53 positive expression rate(79.31％) was higher than that of stage I+Ⅱ patients(26.52％)(P＜0.05),the positive rates of p53 expression in the high,middle and low differentiation degree respectively were 46.43％,72.73％,85.71％,and the positive rate of p53 expression in patients with different degree of differentiation was statistically significant (P＜0.05).The sensitivity of CK19,CD56 and p53 in the differential diagnosis of PMC and PTH were 100％,93.33％,65.33％,The specificity respectively was 67.57％,62.16％,86.49％,and the accuracy respectively was 89.29％,83.04％,72.32％;The sensitivity of CK19 was the highest,and the specificity of p53 was the highest,and the accuracy of CK19 was highest.Conlusions:The high expression of CK19 and p53 in PMC tissue,but also positive expression in PTH tissues,CD56 showed negative expression in PMC,which can be used as auxiliary indexes of CK19 and p53 in the differential diagnosis of PMC and PTH.