3.0T magnetic resonance diffusion weighted imaging diagnosis of pancreatic cancer with lymph node metastasis / 中华胰腺病杂志

ABSTRACT

Objective To explore the diagnostic value of 3.0T MR diffusion weighted imaging(DWI) for metastatic lymph nodes in pancreatic cancer.Methods Thirty patients who were pathologically diagnosed as pancreatic cancer with metastatic lymph nodes were enrolled and all underwent preoperative routine MR DWI examination.TNM staging version 5.0 by JPA in 2002 was used as the grouping criteria for lymph node,and the location of metastatic lymph nodes was analyzed.Apparent diffusion coefficient (ADC) and maximum short axis diameter (MSAD) of lymph nodes were measured,and receiver operating characteristic (ROC) curve was drawn to evaluate the diagnostic value of ADC and MSAD for pancreatic cancer with metastatic lymph nodes.Results The number of lymph nodes was 108 detected by DWI including 54 metastatic lymph nodes and 54 non-metastatic lymph nodes.The metastatic lymph nodes most commonly occurred in group 13,16 and 17 in pancreatic head cancer and group 16 in pancreatic body and tail cancer.The ADC value of metastatic lymph nodes was lower than that of non-metastatic lymph nodes [(1.51 ± 0.28) × 10-3 mm2/s vs (2.08-± 0.35) × 10-3 mm2/s].The MSAD of metastatic lymph nodes was longer than that of non-metastatic lymph nodes [(7.03 ±-2.49) mm vs (4.40 ± 0.97) mm].There were statistically significant differences (all P ＜ 0.001).The areas under the ROC curve of ADC values was 0.894,the best threshold was 1.78 × 10-3mm2/s,and the corresponding sensitivity and specificity was 85.2％ and 85.2％.The areas under the ROC curve of MSAD was 0.876,the best threshold was 5.65 mm,and the corresponding sensitivity and specificity was 68.5％ and 90.7％.Conclusions 3.0T MR DWI had a relatively high diagnostic value for metastatic lymph nodes in pancreatic cancer.