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Correlation between dynamic contrast-enhanced magnetic resonance imaging features and the prognosis and pathological classification of breast cancer / 新乡医学院学报
Journal of Xinxiang Medical College ; (12): 1093-1096, 2017.
Artigo em Chinês | WPRIM | ID: wpr-669324
ABSTRACT
Objective To investigate the correlation between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) features and the prognosis and pathological classification of breast cancer.Methods Forty patients with breast cancer were proved by DCE-MRI and pathological examination in the Third Affiliated Hospital of Xinxiang Medical University from January to December 2016.The DCE-MRI features,estrogen receptor (ER),progesterone receptor (PR),human epidermal growth factor receptor-2 (Her-2) and the pathological classification of breast cancer were collected.The correlation between DCE-MRI features and molecular biology indexes in breast cancer was analyzed by Spearman rank correlation analysis.Results There was no significant correlation between the lesion size and the positive expression rate of ER,PR and Her-2 (r =-0.119,0.063,0.237;P > 0.05).The lesion morphology was positively correlated with the positive expression rate of Her-2(r =0.296,P < 0.05) but there was no significant correlation between the lesion morphology and the expression of ER and PR (r =0.219,0.211;P > 0.05).The lesion enhancement form was negatively correlated with PR positive expression (r =-0.304,P < 0.05),and it was not correlated with the expression of ER and Her-2 (r =0.396,-0.393;P > 0.05).There was no significant correlation between the TIC type of the lesion and the expression of ER,PR and Her-2 (r =0.254,0.315,0.396;P >0.05).The early enhancement rate was positively correlated with Her-2 positive expression (r =0.498,P < 0.05),but there was no correlation between early enhancement rate and the expression of ER and PR(r =0.125,0.241;P > 0.05).The lesion morphology,enhancement and early enhancement rate of the lesion were significantly correlated with the pathological type of breast cancer (r =0.399,0.323,0.513;P < 0.05).The lesion size and the TIC type were not significantly correlated with the pathological type of breast cancer (r =0.313,0.308;P > 0.05).Conclusion The shape,edge and enhancement form of lesion in DCE-MRI are correlated with the prognosis and pathological types of breast cancer;which provides a theoretical basis for the evaluation of biological behavior,prognosis and severity of breast cancer through the imageology.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Journal of Xinxiang Medical College Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo prognóstico Idioma: Chinês Revista: Journal of Xinxiang Medical College Ano de publicação: 2017 Tipo de documento: Artigo