Determination of Amantadine Hydrochloride in Pediatric Paracetamol and Amanatadine Hydrochloride Granules by GC / 中国药师
China Pharmacist
; (12): 1067-1069, 2015.
Article
em Zh
| WPRIM
| ID: wpr-669859
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WPRO
ABSTRACT
Objective:To establish a GC method for determining the content of amantadine hydrochloride in pediatric paracetamol and amanatadine hydrochloride granules. Methods:The ingredients were separated on an Agilent DB-5 quartz capillary column (30 m ×0.25 mm, 0.25 μm), the carrier gas was N2,and the flow rate was 1 ml·min-1. The column temperature was maintained at 130℃, the injection temperature was 250℃,the detection temperature was 280℃ with an FID as the detector , the injection volume was 2 μl, and the split ratio was 20∶1. Results:A good linear relationship was obtained between the peak area and the concentration of amantadine hydrochloride within the range from 0.103 2 to 6.456 0 mg·ml-1(r =0.999 9). The average recovery was 100.18%(RSD=0. 11%, n=6). Conclusion:The method is specific, accurate, reliable and reproducible, which can be used in the quality control of pediatric paracetamol and amanatadine hydrochloride granules.
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WPRIM
Idioma:
Zh
Revista:
China Pharmacist
Ano de publicação:
2015
Tipo de documento:
Article