Changes of Nitric Oxide Metabolite and Tumor Necrosis Factor-alpha in the Urine of Patients with Superficial Bladder Tumors after BCG Immunotherapy / 대한비뇨기과학회지
Korean Journal of Urology
;
: 1327-1332, 1994.
Artigo
em Coreano
| WPRIM
| ID: wpr-67044
ABSTRACT
Bacillus Calmette-Guerin(BCG) is widely used in the therapy of superficial bladder tumors. Clinical and animal studies suggest that immunological responsiveness to BCG antigens correlates with anti-tumor activity. But its mode of action is unclear. In this studies, we evaluated the changes of nitric oxide(NO) metabolite and tumor necrosis factor-alpha(TNF-alpha) in the urine of patients with superficial bladder tumors after BCG immunotherapy. Both NO and TNF-alpha in the urine specimens of patients treated with BCG were analyzed prior to BCG instillation and 4, 8 and 24 hours afterwards. After 6th BCG instillation. urinary NO increased significantly and showed a maximum of secretion at eight hours(p<0.05). After 6th BCG instillation, urinary TNF-alpha increased and showed a maximum of secretion at eight hours but had no statistical significance. These results suggest that intravesical BCG therapy increased the urinary NO and TNF-alpha secretion which may be related to the anti-tumor activity.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Bacillus
/
Bexiga Urinária
/
Neoplasias da Bexiga Urinária
/
Fator de Necrose Tumoral alfa
/
Imunoterapia
/
Mycobacterium bovis
/
Necrose
/
Óxido Nítrico
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
1994
Tipo de documento:
Artigo
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