The effect of BMP-2 on the rabbit's facial nerve wound healing:Histological quantitive analysis and ultrastructural observation / 实用口腔医学杂志

ABSTRACT

Objective: To evaluate the effects of BMP 2 on wound healing of facial nerve. Methods: Facial nerve was crushed in 6 rabbits.1 ng of BMP 2 in 20 ?l of saline was injected around the injured nerve on one side, 20 ?l of saline was injected on the other side as the control.Each two animals were sacrificed 1d,2 and 4 weeks after injury.The nerve samples were studied by histological observation,electron microscopic observation and image pattern analysis.Results:Better healing was observed in BMP 2 treated nerves in 2 and 4 weeks.4 weeks after injury,the axon number on each 100 ?m2 in BMP 2 treated nerves and control ones was 0.946?0.572 and 0.614?0.430(P