Effects of recombinant human vascular endothelial growth factor on proliferation and differentiation of rat osteoblasts / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6)1995.
Artigo
em Chinês
| WPRIM
| ID: wpr-670916
ABSTRACT
Objective:
To study the effects of recombinant human vascular endothelial growth factor on proliferation and differentiation of rat osteoblasts.Methods:
Cell culturing, light microscop, MTT assay and PNPP assay were performed to observe the effects of rhVEGF on proliferation and differentiation of the cells.Results:
rhVEGF could stimulate osteoblasts proliferation and differentiation. The maximal effect on proliferation was observed at a concentration of 3.125 ng/ml on the third day. ALP activities in osteoblasts were increased most significantly at a concentration of 12.5 ng/ml.Conclusion:
rhVEGF may not only induce angiogenesis to facilitate bone formation, but also stimulate this process in a direct way by inducing proliferation and differentiation of osteoblasts.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Practical Stomatology
Ano de publicação:
1995
Tipo de documento:
Artigo
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